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Six-Transmembrane Epithelial Antigen of the Prostate 2
- Molecular classification
- Metalloreductase, Transmembrane protein
01
Overview
Six-transmembrane epithelial antigen of the prostate 2 (STEAP2) is a metalloreductase involved in metal ion reduction and cellular metabolism. It is highly expressed in prostate tissue and prostate cancer cells, making it a potential diagnostic and therapeutic target. STEAP2 functions by reducing extracellular Fe³⁺ to Fe²⁺ for cellular uptake and may also be involved in copper metabolism. Recent structural studies have elucidated its electron transfer mechanism involving FAD and heme groups.
- Other names
- STEAP2
02
Biological functions
Metal ion homeostasis (iron/copper)Reduction of extracellular Fe³⁺ to Fe²⁺Regulation of oxidative stressInflammatory response modulation
03
Disease associations
CancerProstate cancer
04
Safety considerations
Potential for off-target effects due to expression in some normal tissues
05
Biomarkers
Prostate cancer diagnosisTherapeutic target for prostate cancer
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