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Target intelligence / Profile preview
Skeletal Muscle
- Molecular classification
- Tissue
01
Overview
Skeletal muscle is a type of striated muscle tissue that is responsible for voluntary movements, posture maintenance, joint stabilization, and heat generation. It is composed of bundles of muscle fibers (myofibers), which contain myofibrils made up of sarcomeres (the basic contractile units). Contraction is initiated at the neuromuscular junction via acetylcholine signaling, leading to actin-myosin interactions and muscle shortening.
- Other names
- Skeletal striated muscleStriated voluntary musclemuscularis skeletalis
02
Mechanism of action
Various, depending on the specific drug. Neuromuscular blockers interfere with acetylcholine signaling at the neuromuscular junction. Muscle relaxants can act centrally or peripherally to reduce muscle tone.
03
Biological functions
MovementPosture maintenanceJoint stabilizationHeat productionProtection of internal organsRegulation of entry/exit points
04
Disease associations
Muscular disorders (e.g., muscular dystrophy)Locomotor disordersMetabolic disorders (related to heat generation and energy expenditure)
05
Safety considerations
Muscle weaknessFatigueRhabdomyolysis (muscle breakdown)Hyperthermia (related to heat generation)
06
Interacting drugs
Neuromuscular blocking agents
3 more in the full profile.
07
Biomarkers
Creatine kinase (CK)MyoglobinMuscle-specific enzymes (e.g., aldolase)
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