Skeletal muscle fiber regeneration

Skeletal muscle fiber regeneration is a complex, multi-step biological process by which muscle tissue restores its structure and function after damage or injury. This process is primarily mediated by specialized stem cells known as satellite cells, which reside beneath the basal lamina of muscle fibers. Upon injury, satellite cells become activated, proliferate, and differentiate into myoblasts, which subsequently fuse to repair or replace damaged myofibers[1][2][3][4][5]. The regenerative process involves interactions among muscle stem cells, immune cells, fibro-adipogenic progenitors, and vascular cells. Defects in muscle regeneration contribute to muscle degenerative diseases such as muscular dystrophy and sarcopenia. Because it refers to a regenerative process rather than a discrete biomolecule, "skeletal muscle fiber regeneration" is not a direct pharmacological or therapeutic target, though pathways within it may be.

Other names

Skeletal muscle regenerationMuscle fiber repairMuscle regeneration