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Target intelligence / Profile preview
Skeletal Muscle Precursor Cell (Autologous) (MPC)
- Target
- MPC
- Molecular classification
- Stem Cell, Progenitor Cell
01
Overview
Skeletal muscle precursor cells (MPCs), primarily satellite cells, are stem/progenitor cells harvested from an individual's own skeletal muscle and reintroduced to promote regeneration in damaged muscular tissues through differentiation into new myofibers. Their use is under active investigation due to regenerative capacity and low immunogenicity when used autologously.
- Other names
- Skeletal Muscle Progenitor CellMyoblastSatellite Cell
02
Mechanism of action
Cellular therapy involving direct differentiation and integration into damaged tissue.
03
Biological functions
Skeletal muscle regenerationMyofiber formationTissue repairCell proliferationCell differentiation
04
Disease associations
Urethral sphincter insufficiencyStress urinary incontinenceMyocardial infarctionMuscle injury
05
Safety considerations
Limited large-scale human clinical trialsOptimization of cell dose and delivery method requiredLong-term safety needs further investigationEfficacy in humans needs further confirmation
06
Biomarkers
Pax7Myf5CD34M-cadherinc-Metα7-integrinSyndecan 3Syndecan 4
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