Skeletal myoblast

Skeletal myoblasts are mononucleated progenitor (precursor) cells that arise from the paraxial mesoderm during development and remain resident in adult skeletal muscle as satellite cells. Upon activation (for example, in response to muscle injury), they proliferate and then differentiate by fusing to form multinucleated myotubes, which mature into skeletal muscle fibers. These cells express molecular markers such as Pax7, MyoD, and desmin, and play an essential role in skeletal muscle formation, regeneration, and repair throughout life. In regenerative medicine, skeletal myoblasts have been explored as a potential cell therapy for myocardial repair and muscular dystrophies; however, they are not a single molecular target but a cell population, and thus are not directly druggable in the sense of conventional receptors or enzymes[1][3][4][7].

Other names

MyoblastMuscle progenitor cellSkeletal muscle precursor cell