Skin and skin microbiome ecosystem

The skin and skin microbiome ecosystem is a complex biological environment comprising human skin cells and a diverse array of microorganisms, including bacteria, fungi, viruses, and mites (Byrd et al., 2018, Nature Reviews Microbiology). This ecosystem functions as a critical physical and immunological barrier, where commensal microbes compete with pathogens for nutrients and produce antimicrobial substances to prevent colonization by harmful species (Grice & Segre, 2011, Nature Reviews Microbiology). It also plays a vital role in educating the host immune system and maintaining skin homeostasis (Belkaid & Segre, 2014, Science). Disruptions to this delicate balance, termed dysbiosis, are associated with various dermatological disorders, including atopic dermatitis, acne vulgaris, and psoriasis (Kong et al., 2012, Genome Research). Therapeutic interventions targeting this ecosystem range from traditional antibiotics and antifungals to emerging approaches like probiotics, prebiotics, and microbiome transplants designed to restore microbial diversity and function (Wallen-Russell, 2019, Cosmetics). Understanding the symbiotic relationship between the host and its microbiota is essential for developing precision treatments for skin diseases.

Other names

Skin microbiotaSkin floraCutaneous microbiomeDermal microbiome

Modulation of the microbial community structure and host-microbe interactions to restore skin homeostasis and barrier function (Byrd et al., 2018, Nature Reviews Microbiology).