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Physical occlusion enhances skin barrier function by creating a protective layer on the skin surface. This layer reduces water evaporation, increases hydration, shields against environmental factors, and can influence local inflammatory responses during the healing process. This is a biophysical intervention rather than a receptor-mediated process, modifying physiological processes at the tissue level through mechanical means.
Formation of an impermeable or semi-permeable film on the skin surface to reduce transepidermal water loss, protect against external irritants, and enhance hydration of the stratum corneum. This mechanism indirectly modulates inflammatory pathways and improves barrier function.
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