Skin barrier function regulators

Skin barrier function regulators encompass a diverse array of proteins, lipids, and signaling pathways that collectively maintain the skin's physical and chemical integrity (PubMed: 29054331). The primary component is the stratum corneum, where corneocytes are cross-linked by proteins like filaggrin and loricrin and surrounded by a lipid-rich matrix of ceramides and fatty acids (PubMed: 24290385). These regulators are critical for preventing transepidermal water loss (TEWL) and shielding the body from environmental pathogens and allergens. In diseases such as atopic dermatitis and psoriasis, the expression or function of these regulators is compromised, leading to barrier breakdown and chronic inflammation. Therapeutic intervention often focuses on restoring this barrier, either through direct lipid replacement or by modulating upstream signaling pathways. For instance, tapinarof acts as an aryl hydrocarbon receptor (AhR) agonist to upregulate the production of structural proteins, while biologics like dupilumab indirectly support barrier repair by inhibiting Th2 cytokines that downregulate filaggrin (PubMed: 28619861, FDA).

Other names

Epidermal barrier regulatorsSkin barrier proteinsCornified envelope proteinsSkin barrier components

Restoration of the physical and chemical barrier through the upregulation of structural proteins (e.g., filaggrin) and lipids, or by inhibiting inflammatory cytokines that degrade barrier integrity (PubMed: 29054331, PubMed: 28619861).