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Skin Barrier Lipid

Molecular classification: Lipid, Ceramide, Cholesterol, Fatty Acid

Overview

Skin barrier lipids are a group of specialized lipids located primarily in the stratum corneum. These lipids play a critical role in maintaining skin barrier function, which is essential for preventing transepidermal water loss (TEWL) and protecting against external irritants, allergens, and pathogens. The main lipid classes are ceramides, cholesterol, and free fatty acids, forming a "brick and mortar" arrangement between corneocytes.

Biological functions

Maintains skin hydrationPrevents transepidermal water loss (TEWL)Protection against external irritantsProtection against allergensProtection against pathogensStructural integrity of stratum corneum

Disease associations

Atopic dermatitisEczemaDry skinAllergic diseasesCompromised skin barrier function

Biomarkers

Ceramide levels in stratum corneumCholesterol levels in stratum corneumFatty acid levels in stratum corneumTransepidermal water loss (TEWL)

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