Skin cell cohesion protein

"Skin cell cohesion proteins" is not the canonical name for any single molecular target but rather refers collectively to several families of structural and signaling proteins that mediate cell-cell adhesion in the epidermis. These include cadherins such as E-cadherin and desmosomal cadherins like desmogleins and desmocollins, tight junction components such as claudins and occludin, integrins involved in cell-matrix interactions, adaptor proteins like plakoglobin and plakophilins linking cytoskeletal elements to membrane complexes, as well as specialized structural proteins including filaggrin which contributes to terminal differentiation and compaction of keratinocytes[3][6][7][8]. These molecules are essential for maintaining epidermal integrity by forming adherens junctions, tight junctions, gap junctions, hemidesmosomes, and desmosomes between keratinocytes throughout all layers of the epidermis. Dysfunction or genetic defects affecting these molecules can result in various dermatological conditions characterized by loss of cohesion between skin cells or impaired barrier function[5][8]. Note: The term provided is too broad/generic for structured data extraction about one specific therapeutic target. For structured information on druggability or biomarker status it is necessary to specify an exact molecule—such as "Desmoglein 1," "E-cadherin," or "Filaggrin."

Other names

Cell adhesion moleculeCell-cell junction proteinEpidermal adhesion proteinJunctional complex protein

null (as a group; mechanisms depend on the specific molecule targeted—e.g., inhibition of autoantibody binding in autoimmune disease)