Skin disorder

The term 'Skin disorder' refers to a broad clinical category of conditions affecting the integumentary system rather than a specific molecular target such as a receptor, enzyme, or transcription factor. This category encompasses a diverse range of pathologies including inflammatory dermatoses like psoriasis and atopic dermatitis, various skin cancers, and genetic disorders such as ichthyosis [1, 5, 12]. In the context of drug development, researchers focus on specific molecular entities within these diseases, such as Janus kinases (JAK), interleukins (e.g., IL-17, IL-23, IL-4), or the Vitamin D receptor [2, 4, 8, 13]. These molecules serve as the actual therapeutic targets that regulate critical biological functions, including immune signaling, cell differentiation, and the maintenance of the epidermal barrier [6, 9]. Because 'Skin disorder' represents an overarching clinical indication involving numerous distinct biological pathways and potential targets, it does not fulfill the criteria for a single, discrete therapeutic target [11]. Distinguishing between a disease category and its underlying molecular targets is essential for the design and success of targeted dermatological therapies [10].

Other names

Skin diseasesDermatological conditionsCutaneous diseasesDermatosesSkin disorders

Not applicable; the entry refers to a disease category rather than a specific molecular target.