Skin microbiome modulation

"Skin microbiome modulation" refers to the intentional alteration—by natural, induced, or engineered means—of the structure and function of the microbial communities residing on human skin. This is not a single molecule or receptor but rather a therapeutic strategy aimed at restoring healthy balance among resident microorganisms. Approaches include topical application of probiotics or antibiotics, use of phototherapy alongside antimicrobials, dietary interventions affecting systemic immunity and thus local flora, and advanced synthetic biology techniques to engineer beneficial strains. The goal is often to reduce dysbiosis-associated disease states such as acne vulgaris, eczema, psoriasis, infections like Staphylococcus aureus overgrowths, wound healing complications, and even certain cancers like cutaneous T-cell lymphoma. While promising for novel therapies that target underlying causes rather than symptoms alone[1][2][3], "skin microbiome modulation" itself is not a molecular target but an intervention concept encompassing multiple potential targets within the complex ecosystem of the skin's surface. "Manipulation of the skin microbiome entails the promise of novel therapeutic strategies for skin diseases… We are particularly interested in Cutibacterium acnes… as this bacterium represents a major part… certain strains are associated with deviation in the microbiome which probably causes acne vulgaris."[1] "Modulating [the] microbiota by topical antibiotic treatment helps restore microbial balance by diminishing numbers of pathogenic microbes… reduces chronic inflammation [and] delays tumour growth…"[2] Note: This entry does not correspond to a specific protein/receptor/enzyme/transporter; it describes an approach/strategy involving many possible molecular targets within diverse bacterial species on human skin. Therefore, - is_target should be marked false - is_incorrect should be marked true, since this is not a canonical druggable target but rather an area/intervention strategy

Other names

Microbiome modulation (skin)Modulation of skin microbiotaSkin microbial community modulation

Restoration or alteration of microbial balance by reducing pathogenic microbes and increasing commensal populations[2][3]; Immune system modulation via changes in microbial composition[5]; Reduction in chronic inflammation through decreased pathogen load[2].