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Target intelligence / Profile preview
Skin Microbiome
- Molecular classification
- Microbial Community, Ecosystem
01
Overview
The skin microbiome is a complex ecosystem of microorganisms residing on and within human skin. It plays a crucial role in maintaining skin health by acting as a protective barrier against pathogens, modulating the immune system, and contributing to homeostasis. Imbalances in the skin microbiome are associated with various dermatological diseases.
- Other names
- Cutaneous MicrobiomeSkin MicrobiotaMicrobial Flora of the Skin
02
Mechanism of action
Varies depending on the specific therapeutic approach. Probiotics and prebiotics aim to restore microbial balance. Bacteriophage therapy targets specific pathogenic bacteria. Antimicrobials reduce the overall microbial load.
03
Biological functions
Pathogen DefenseImmune System ModulationHomeostasisNutrient CompetitionAntimicrobial ProductionEpidermal Barrier Maintenance
04
Disease associations
Atopic DermatitisPsoriasisAcne VulgarisRosaceaDysbiosis-associated diseases
05
Safety considerations
Potential for opportunistic infectionsDevelopment of antimicrobial resistanceUnintended consequences of microbiome manipulationVariability in individual responses to therapeutic interventions
06
Interacting drugs
Probiotics
3 more in the full profile.
07
Biomarkers
Bacterial species relative abundanceFungal species relative abundanceMicrobial diversity indices (e.g., Shannon diversity)Specific microbial metabolitesHost immune response markers (e.g., cytokines)
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