Skin regeneration using cultured autologous keratinocytes and fibroblasts on biocompatible scaffold

This entity describes a **skin regenerative therapy** that uses a combination of **autologous keratinocytes** (epithelial cells responsible for re-epithelialization) and **fibroblasts** (dermal cells producing extracellular matrix and supporting structural integrity) cultured and expanded outside the body, then seeded onto a **biocompatible scaffold** designed to mimic the skin’s physical structure. This engineered skin is then grafted onto wounds or defects, leveraging the cells’ ability to proliferate, differentiate, and produce necessary matrix components for tissue regeneration. The approach addresses limitations in standard skin grafts and enhances wound closure, skin maturation, and functional recovery. The scaffold may be made of biomaterials such as collagen, hyaluronic acid, or synthetic polymers, providing support and spatial organization for the implanted cells[1][2][4][6]. Direct drug targeting is not applicable, but adjuncts such as growth factors may further support the regenerative process.\n\nIn summary, this is not a classical drug target or receptor, but a complex regenerative technique using cultured cells and biomaterials for advanced skin healing.

Other names

Autologous cell suspension for skin regenerationTissue-engineered skin substitute (TESS) using keratinocytes/fibroblastsComposite skin substitute (CSS)Skin regenerative units (TESRU)

Physical and biological support for tissue regeneration\n- Promotion of keratinocyte and fibroblast growth, migration, and matrix synthesis\n- Paracrine signaling via secreted growth factors and cytokines