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Target intelligence / Profile preview
Skin Surface Proteins
- Molecular classification
- Structural Proteins, Cytokines, Chemokines, Peptides, Enzymes
01
Overview
Skin surface proteins are a diverse group of molecules present on or near the outermost layer of the skin, primarily within the stratum corneum and epidermis. These proteins play critical roles in maintaining skin barrier function, mediating immune responses, and serving as biomarkers for various dermatological conditions. They include structural proteins like keratin, immune/inflammatory markers such as cytokines and chemokines, and peptides used in skincare. Their levels and activity are often altered in skin diseases.
- Other names
- Epidermal ProteinsStratum Corneum Proteins
02
Mechanism of action
Varies widely depending on the specific protein and the drug. Examples include: reducing inflammation, inhibiting immune cell activation, promoting collagen synthesis, modulating nerve signaling.
03
Biological functions
Barrier FunctionCell AdhesionImmune ResponseInflammationAntimicrobial DefenseCollagen SynthesisWound HealingCell Signaling
04
Disease associations
PsoriasisAtopic DermatitisSkin AgingGenetic Skin DisordersBlistering DiseasesSkin CancerInfections
05
Safety considerations
Potential for allergic reactions to topical peptides.Systemic absorption of topical corticosteroids.Immunosuppression with biologics.Penetration depth of peptides in skincare.
06
Interacting drugs
Topical Corticosteroids
3 more in the full profile.
07
Biomarkers
IL-1RAhBD-2IL-8/CXCL8CXCL1/2VEGFIL-23CCL27IL-22Keratin levelsDesmosomal protein levels
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