Skin wound healing response

The skin wound healing response is a coordinated, multi-step biological program engaged to restore tissue integrity following injury. It involves the interplay of hemostasis, inflammation, proliferation, and remodeling[1][2][3][4][5][6]. Key cellular participants include keratinocytes, fibroblasts, endothelial cells, neutrophils, lymphocytes, and macrophages. These cells communicate via cytokines, chemokines, growth factors, and extracellular matrix molecules, orchestrating processes like blood clot formation, immune cell recruitment, new tissue formation, and scar deposition[1][2][3][4][5][6]. The response may culminate in complete regeneration or in formation of fibrotic scar tissue. The process can be dysregulated in disease states such as diabetes, chronic wounds, or excessive fibrosis, making components of the wound healing response—rather than the process itself—potential therapeutic targets. Because “Skin wound healing response” denotes a complex process rather than a specific molecule or receptor, it does not conform to typical molecular target structure and is considered **incorrect as entered for this context**. Individual molecules (e.g., TGF-β, VEGF, PDGF) or cell surface receptors mediating wound healing are appropriate entries if a molecular target is required[1][5][6].

Other names

Wound healing responseSkin repair processCutaneous wound healing