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Target intelligence / Profile preview
SKP2 pseudogene 1 (SKP2P1)
- Target
- SKP2P1
- Molecular classification
- Pseudogene
01
Overview
SKP2 pseudogene 1 (SKP2P1) is a non-coding genomic locus designated as a pseudogene and is homologous to the SKP2 gene. Unlike SKP2, which encodes an F-box protein functioning as the substrate recognition subunit of the SCF (SKP1-CUL1-F-box) E3 ubiquitin ligase complex and acts as an oncogene involved in cell cycle regulation and several cancers[1][3][5][9], SKP2P1 does not encode a functional protein and has no known role in human biology, disease, or drug action. Caution is advised to avoid confusion with SKP2, as only the latter is a validated oncologic target and a member of the F-box protein family.
- Other names
- SKP2P1F-box and leucine-rich repeat protein 21 pseudogene 1
02
Mechanism of action
None
03
Biological functions
None (Pseudogenes generally lack biological function, unless evidence exists for regulatory/non-coding RNA function, which is not described for SKP2P1.)
04
Disease associations
None direct; SKP2P1 is not described as directly implicated in disease.
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