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SLAM family member 7 (SLAMF7)
- Target
- SLAMF7
- Molecular classification
- Type I transmembrane protein, Immunoglobulin superfamily receptor
01
Overview
SLAM family member 7 (SLAMF7), also known as CS1 or CD319, is a type I transmembrane glycoprotein belonging to the signaling lymphocytic activation molecule (SLAM) family of receptors. It functions as a self-ligand receptor involved in immune cell regulation, acting as an activating or inhibitory receptor depending on the cellular context and adaptor protein interactions. It is overexpressed in multiple myeloma and targeted by elotuzumab.
- Other names
- CS1CD319CRACC19AMembrane protein FOAP-12Novel Ly9
02
Mechanism of action
Enhances NK-cell mediated cytotoxicity against tumor plasma cells
03
Biological functions
Immune cell activationImmune cell regulationSignal transduction
04
Disease associations
Multiple myelomaCancerInflammation
05
Interacting drugs
Elotuzumab
06
Biomarkers
SLAMF7 expression in plasma cells (for multiple myeloma diagnosis and monitoring)
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