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SLC26A5 antisense RNA 1 (SLC26A5-AS1)

Target: SLC26A5-AS1
Molecular classification: Other (Long non-coding RNA)

Overview

SLC26A5 antisense RNA 1 (SLC26A5-AS1) is a long non-coding RNA gene located on human chromosome 7q22.1. It is annotated as the antisense transcript overlapping the SLC26A5 (solute carrier family 26 member 5, also known as prestin) gene. SLC26A5-AS1 belongs to the lncRNA class and is characterized by a lack of protein-coding capacity. While the principal function of most antisense lncRNAs is to modulate the expression of their sense gene partners through diverse epigenetic or transcriptional mechanisms, the specific biological function of SLC26A5-AS1 has not yet been established experimentally. The gene is listed in public databases (NCBI Gene: 101927870, Ensembl: ENSG00000234715) but lacks thorough functional or clinical characterization. Genetic studies have associated SLC26A5-AS1 loci with lissencephaly 2 and familial temporal lobe epilepsy type 7, although the mechanistic basis is unclear. Currently, there are no drugs known to interact with SLC26A5-AS1, nor is it used as a biomarker in clinical practice.

Other names: CTB-107G13.1SLC26A5-AS1

Biological functions

Putative regulation of SLC26A5 gene expression (by antisense mechanism or RNA-level regulation)General lncRNA involvement in regulation of gene expression, chromatin modification, or transcript stability is likely but not yet demonstrated specifically for this transcript

Disease associations

Genetic association reported with Lissencephaly 2Genetic association reported with familial temporal lobe epilepsy, type 7No evidence for other specific disease roles to date

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