SLC39A13 antisense RNA 1 (SLC39A13-AS1)

SLC39A13 antisense RNA 1 (SLC39A13-AS1), also known as LOUP or “long noncoding RNA originating from the URE of PU.1,” is a long noncoding RNA transcribed antisense to the SLC39A13 locus and upstream of the transcription factor PU.1 (encoded by SPI1). SLC39A13-AS1/LOUP functions as a regulatory RNA controlling the expression of PU.1, a master regulator of myeloid development, by acting specifically in myeloid lineages to enable efficient transcriptional activation of PU.1 from a distal enhancer. It is not a protein, receptor, or “druggable” target in the classical sense, but it does modulate critical biological processes governing hematopoietic differentiation and has implications for hematopoietic cancers and immune cell development. In summary, SLC39A13-AS1 is a functionally relevant lncRNA, central to the regulation of PU.1, with emerging possible roles in cancer biology, but is not a classical target such as a small-molecule receptor or enzyme. No therapeutics or drugs presently target this RNA.

Other names

LOUPAC090559.1Long noncoding RNA originating from the URE (upstream regulatory element) of PU.1SLC39A13 antisense RNA 1SLC39A13-AS1

Not applicable for drugs, since none are known. For biological mechanism: Functions primarily through regulation of adjacent gene transcription (particularly PU.1/SPI1) by mechanisms typical of lncRNAs: cis-regulatory chromatin effects, possibly as a scaffold or through RNA–protein interactions.