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SLC5A4 antisense RNA 1 (SLC5A4-AS1)
- Target
- SLC5A4-AS1
- Molecular classification
- Long non-coding RNA (lncRNA), Antisense RNA, Non-coding RNA gene
01
Overview
SLC5A4 antisense RNA 1 (SLC5A4-AS1) is a long non-coding RNA gene located on chromosome 22 that is transcribed antisense to the SLC5A4 protein-coding gene[2][4][5]. It is part of the lncRNA and antisense RNA family, typified by roles in transcriptional or epigenetic regulation rather than coding for proteins. SLC5A4-AS1 has not been established as a therapeutic target, although its expression may be dysregulated in certain diseases such as juvenile myelomonocytic leukemia. There is no evidence for drug interaction or biomarker use, and its biological function is not fully characterized, which is consistent with many lncRNAs[2][3][5][7]. In summary, SLC5A4-AS1 is a non-coding RNA gene, not a classical drug target, notable for disease-related differential expression but lacking concrete data on direct biological functions, therapeutics, or safety concerns.
- Other names
- RP1-90G24.10SLC5A4-AS1GC22P032206
02
Mechanism of action
Not applicable. SLC5A4-AS1 is not a target for drugs; no known mechanism of drug targeting. Knockdown effects for other lncRNAs may use antisense oligonucleotides (e.g., GapmeRs), but no validated interventions for SLC5A4-AS1
03
Biological functions
Regulation of gene expression (as with other antisense lncRNAs, potentially modulating neighboring gene SLC5A4 but specific function for SLC5A4-AS1 is not established)
04
Disease associations
Differential expression reported in subgroups of juvenile myelomonocytic leukemia patients, suggesting a possible association but no confirmed causative role or biomarker function
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