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Target intelligence / Profile preview
SLC6A1 antisense RNA 1 (SLC6A1-AS1)
- Target
- SLC6A1-AS1
- Molecular classification
- Long non-coding RNA (lncRNA), Antisense RNA, Non-protein coding
01
Overview
SLC6A1 antisense RNA 1 (SLC6A1-AS1) is a long non-coding RNA located on chromosome 3, transcribed in the antisense direction to the SLC6A1 gene, which codes for the GABA transporter protein. SLC6A1-AS1 does not produce a protein; it may play a regulatory role in the expression of the SLC6A1 gene. Studies have associated changes in its expression with several diseases, including hepatocellular carcinoma, cholangiocarcinoma, retinoblastoma, and Alzheimer's disease, often as a biomarker for prognosis or risk stratification. No compounds are known to directly target SLC6A1-AS1; its biology is primarily of interest for understanding gene regulation and disease mechanisms.
- Other names
- SLC6A1 antisense RNA 1 (non-protein coding)SLC6A1-AS1HSALNG0024134NONHSAG034433.2ENSG00000232287ENSG00000232287.2
02
Mechanism of action
Not applicable. No drugs or therapeutic agents are reported to act on SLC6A1-AS1 directly
03
Biological functions
Regulation of gene expression (speculative; possibly regulates neighboring SLC6A1 gene)
04
Disease associations
Cancer (cholangiocarcinoma, hepatocellular carcinoma, retinoblastoma)Potential involvement in Alzheimer's disease (downregulated in AD)
05
Safety considerations
None reported or known. SLC6A1-AS1 is not a direct therapeutic target and does not have associated safety or toxicity profiles
06
Biomarkers
Prognostic marker in cholangiocarcinoma, retinoblastoma, and hepatocellular carcinoma (identified in risk models and survival association studies)Downregulation associated with disease prognosis
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