SLCO4A1 antisense RNA 1 (SLCO4A1-AS1)

SLCO4A1 antisense RNA 1 (SLCO4A1-AS1) is a long non-coding RNA (lncRNA) located on chromosome 20, transcribed antisense to the SLCO4A1 gene. It functions as a competing endogenous RNA (ceRNA), sequestering microRNAs and thereby modulating the expression of oncogenes such as IKKα and XIAP. SLCO4A1-AS1 is upregulated in multiple cancer types, including non-small cell lung cancer, gastric cancer, colorectal cancer, and bladder cancer, where it promotes tumor cell proliferation, migration, invasion, and inhibits apoptosis largely through modulation of pathways like NF-κB and by influencing apoptosis regulators. These findings suggest that SLCO4A1-AS1 represents a potential biomarker and novel therapeutic target in several oncologic contexts, although it is not currently associated with any approved drug therapies and research is at an early stage.

Other names

SLCO4A1-AS1LncRNA SLCO4A1-AS1

Acts as a molecular sponge for microRNAs (such as miR-223-3p in NSCLC and miR-149 in gastric cancer) to regulate target mRNA expression (such as IKKα or XIAP), thereby influencing signaling pathways (e.g., NF-κB). Post-transcriptional regulation of oncogenes via ceRNA network.