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Sleeping Beauty Transposase (SB Transposase)
- Target
- SB Transposase
- Molecular classification
- Enzyme, Transposase, DNA-modifying enzyme
01
Overview
Sleeping Beauty transposase is an engineered enzyme used for genome integration via the Sleeping Beauty transposon system. It mediates a "cut-and-paste" mechanism to excise a DNA segment (transposon) and integrate it into a target genome. While it preferentially integrates at TA dinucleotide sites, engineered variants aim to improve targeting specificity and safety profiles. Applications include gene therapy, functional genomics, and biotechnology.
- Other names
- SBSleeping BeautySB100X (hyperactive variant)
02
Mechanism of action
Cut-and-paste transposition; excises DNA flanked by ITRs and integrates it into the genome at TA dinucleotide sites.
03
Biological functions
Genome integrationDNA excisionDNA recombinationGene transfer
04
Disease associations
Genetic diseases (potential target for gene therapy)Cancer (potential tool for cancer research and therapy)
05
Safety considerations
Genotoxicity due to random insertionDisruption of endogenous genes or regulatory elementsInsertional mutagenesis
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