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Target intelligence / Profile preview
SLIT and NTRK like family member 4 (SLITRK4)
- Target
- SLITRK4
- Molecular classification
- Transmembrane protein, Receptor-like protein, Leucine-rich repeat (LRR) family, Other (SLITRK family)
01
Overview
SLIT and NTRK like family member 4 (SLITRK4) is a transmembrane protein belonging to the SLITRK family, characterized by two N-terminal leucine-rich repeat (LRR) domains similar to those in axon guidance proteins SLIT, and C-terminal regions with resemblance to neurotrophin receptors[1][3][5]. SLITRK4 is implicated in the regulation of neuronal development, with functions including suppression of neurite outgrowth and roles in synaptogenesis and synapse differentiation[1]. Altered function of its homologs in mammals has been linked to neurodevelopmental and neuropsychiatric disorders, including autism spectrum disorder and certain brain tumors[1]. No interacting drugs or direct therapeutic applications have yet been approved, and its molecular mechanisms and possible clinical targeting remain subjects of ongoing research[1][3].
- Other names
- SLITRK4SLIK4SLIT and NTRK-like protein 4
02
Mechanism of action
null
03
Biological functions
SynaptogenesisSynapse differentiationSuppression of neurite outgrowthProtein–protein interactions at synapses
04
Disease associations
Autism spectrum disorderSupratentorial primitive neuroectodermal tumorOther potential neurological or psychiatric disorders
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