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Target intelligence / Profile preview
SLIT and NTRK-like protein 2 (SLITRK2)
- Target
- SLITRK2
- Molecular classification
- Transmembrane protein, Cell adhesion molecule, Synaptic organizer, Other
01
Overview
SLIT and NTRK-like protein 2 (SLITRK2) is a single-pass transmembrane protein predominantly expressed in postsynaptic neurons, functioning as a synaptic cell-adhesion molecule. It promotes neurite outgrowth, regulates the development and maintenance of excitatory synapses, and is involved in synaptogenesis. The extracellular region of SLITRK2 comprises two N-terminal leucine-rich repeat (LRR) domains, structurally similar to those in SLIT proteins, which mediate binding with receptor protein tyrosine phosphatases (notably PTPδ). Genetic variants in SLITRK2 are implicated in X-linked neurodevelopmental disorders, with pathogenic mutations disrupting synaptic signaling and neuronal circuit integrity. No current drugs are described that target SLITRK2 directly, and due to its essential neurological functions, therapeutic manipulation may carry risks of cognitive or behavioral side effects.
- Other names
- SLITRK2CXorf2KIAA1854SLITL1TMEM257XLID111transmembrane protein 257slit and trk like gene 2slit-like 1
02
Biological functions
Promotion of excitatory synapse differentiationSynaptogenesisRegulation of neurite outgrowthMaintenance of excitatory synapsesPostsynaptic signaling
03
Disease associations
Neurodevelopmental disorderNeuropsychiatric disorderIntellectual disabilityOther
04
Safety considerations
Potential for neurodevelopmental adverse effects if targetedPossible impairment of synaptic development or function
05
Biomarkers
SLITRK2 protein variants (for X-linked neurodevelopmental disorders)
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