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Target intelligence / Profile preview
SLIT and NTRK-like protein 6 (SLITRK6)
- Target
- SLITRK6
- Molecular classification
- Transmembrane protein, SLITRK family
01
Overview
SLITRK6 is a transmembrane protein primarily expressed in neural tissues, including the inner ear and eye. It belongs to the SLITRK family and plays a crucial role in neuronal development, specifically in hearing and vision. Mutations are associated with deafness and high myopia. It is also being explored as a target for cancer therapy using antibody-drug conjugates.
- Other names
- DFNMYPslit and trk like gene 6SLIT and NTRK-like family, member 64832410J21RikFLJ22774slit and trk like gene 6 precursorRP11‑272M24.2
02
Mechanism of action
Antibody-drug conjugate targeting SLITRK6 for cancer therapy.
03
Biological functions
Neuronal growth and survivalNeurite outgrowth modulationRegulation of eye growthAuditory signal transmission
04
Disease associations
Hearing lossMyopiaUrothelial cancer
05
Interacting drugs
ASG‑15ME
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