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Target intelligence / Profile preview
Slit Guidance Ligand 2 (SLIT2)
- Target
- SLIT2
- Molecular classification
- Secreted glycoprotein, Guidance cue ligand
01
Overview
Slit guidance ligand 2 (SLIT2) is a secreted glycoprotein that acts as a molecular guidance cue, primarily involved in the regulation of cellular migration. It functions mainly through interaction with Roundabout (Robo) family receptors, playing critical roles in axon guidance, neuronal migration, and leukocyte migration. Emerging evidence links SLIT2 to inflammatory responses and gestational diabetes mellitus. It has multiple transcript variants due to alternative splicing, potentially giving rise to functionally distinct protein isoforms.
02
Mechanism of action
Binds to Robo receptors, modulating cytoskeletal rearrangements.
03
Biological functions
Axon guidanceNeuronal migrationLeukocyte migrationCellular migration regulation
04
Disease associations
InflammationPeriodontitisGestational diabetes mellitus
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