Slow Sodium Channel (None)

The slow sodium channel, also known as the persistent sodium current (INaP), is a non-inactivating or slowly inactivating component of the voltage-gated sodium current. It persists at subthreshold voltages and does not fully inactivate during sustained depolarizations. INaP regulates neuronal excitability, contributes to action potential bursting and pacemaking, and is implicated in epilepsy and cardiac arrhythmia. The current is primarily mediated by voltage-gated sodium channels (NaVs), with the Nav1.6 isoform being particularly important. Multiple mechanisms contribute to its persistence, including modal gating, window current, and auxiliary subunit modulation. Its magnitude can be dynamically regulated by various factors, including alternative mRNA splicing, extracellular calcium concentration, protein kinases, G-protein coupled receptors, and oxygen concentration.

Other names

Persistent Sodium CurrentINaP

Inhibition of persistent sodium current