Target intelligence / Profile preview

Smad family member 8 (SMAD8)

Target: SMAD8
Molecular classification: Transcription factor, R-Smad

Overview

Smad family member 8 (SMAD8), also known as SMAD9 or MADH6, is a receptor-regulated SMAD (R-SMAD) that mediates signaling by bone morphogenetic proteins (BMPs). Upon activation by BMP receptors, SMAD8 forms complexes with co-Smad4 and translocates to the nucleus to regulate target gene expression. It plays a critical role in cell growth, apoptosis, morphogenesis, development, and immune responses. The protein's activity is tightly regulated through phosphorylation and ubiquitination, ensuring precise control over BMP-mediated gene expression.

Other names: SMAD9MADH6

Mechanism of action

Modulation of BMP signaling pathway

Biological functions

Signal transductionCell growthApoptosisMorphogenesisDevelopmental processesImmune responseRegulation of gene expression

Disease associations

CancerDevelopmental disorders

Safety considerations

Potential for off-target effects due to broad role in development and tissue homeostasis

Beyond the preview

Go deeper on Smad family member 8 (SMAD8).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Smad family member 8 (SMAD8).

Explore the full profile