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SMAD specific E3 ubiquitin protein ligase 1
- Molecular classification
- E3 ubiquitin ligase, HECT family E3 ubiquitin ligase
01
Overview
SMURF1 is an E3 ubiquitin-protein ligase that plays a critical role in regulating the BMP and TGF-beta signaling pathways by mediating the ubiquitination and subsequent degradation of SMAD proteins. It is involved in cell motility, migration, proliferation, inflammatory responses, and has been implicated in various cancers and lupus nephritis.
- Other names
- SMURF1
02
Mechanism of action
Ubiquitination and proteasomal degradation of target proteins, particularly SMADs
03
Biological functions
Protein ubiquitinationBMP signaling regulationTGF-beta signaling regulationCell motilityCell migrationRegulation of cell proliferationRegulation of inflammatory responses
04
Disease associations
CancerLupus nephritis
05
Safety considerations
Potential for off-target effects due to broad substrate specificity of ubiquitin ligasesComplex role in cancer, with potential for both tumor-suppressing and tumor-promoting effects depending on context
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