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Smad Ubiquitination Regulatory Factor 1
- Molecular classification
- E3 ubiquitin-protein ligase, Enzyme, NEDD4 subfamily
01
Overview
SMURF1 is an E3 ubiquitin ligase that negatively regulates the BMP and TGF-beta signaling pathways by ubiquitinating and targeting key signaling molecules, such as R-SMADs and receptors, for proteasomal degradation. It plays diverse roles in cellular physiology, including cell growth, morphogenesis, migration, and development, and is implicated in various diseases, including cancer, cardiovascular diseases, and immune disorders. Its activity is regulated by phosphorylation and interactions with substrates and adaptors.
- Other names
- SMURF1
02
Mechanism of action
E3 ubiquitin ligase mediating the transfer of ubiquitin to substrate proteins, targeting them for proteasomal degradation
03
Biological functions
Protein ubiquitinationProtein degradationNegative regulation of BMP signalingNegative regulation of TGF-beta signalingCell growth and morphogenesisCell migrationCell polarityEmbryonic developmentBone formation/osteoblast differentiationSelective autophagyNeurite outgrowthInnate immune response modulation
04
Disease associations
CancerBreast CancerGastrointestinal CancersGastric CancerClear cell renal cell carcinomaPancreatic CancerCardiovascular diseasesLiver steatosis/fatty liver diseaseHypertensionInflammationNeurodegenerative disordersHIV
05
Safety considerations
Context-dependent tumor promoter or suppressor role in cancerPotential for off-target effects due to broad substrate range
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