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Small Cajal body-specific RNA 1 (SCARNA1)
- Target
- SCARNA1
- Molecular classification
- Small nucleolar RNA (snoRNA), Small Cajal body-specific RNA (scaRNA), H/ACA box RNA
01
Overview
Small Cajal body-specific RNA 1 (SCARNA1/ACA35) is a non-coding small nucleolar RNA localized in the Cajal bodies of the cell nucleus. It is a member of the H/ACA box scaRNA family and serves as a guide RNA for pseudouridylation of U2 spliceosomal RNA at residue U89. By aiding post-transcriptional modification of snRNA, SCARNA1 participates in the assembly and function of the spliceosome complex, contributing to accurate and regulated pre-mRNA splicing. While scaRNAs are crucial for RNA maturation and cell viability, SCARNA1 itself is not considered a classical drug or therapeutic target.
- Other names
- ACA35ACA35 scaRNASCARNA1
02
Biological functions
Guides pseudouridylation of U2 spliceosomal RNARegulation of spliceosome assembly and functionPost-transcriptional modification of snRNA
03
Disease associations
Other (Indirect roles: snoRNAs and scaRNAs are involved in genome stability, cell cycle regulation, and can play roles in cancer and developmental diseases by regulating RNA modifications, but SCARNA1's standalone disease association is not specifically established.)
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