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Small Cajal body-specific RNA 14 (SCARNA14)
- Target
- SCARNA14
- Molecular classification
- Small nucleolar RNA (snoRNA), Small Cajal body-specific RNA (scaRNA), Non-coding RNA
01
Overview
Small Cajal body-specific RNA 14 (SCARNA14, also known as U100) is a small nucleolar RNA that localizes to Cajal bodies in the nucleus of eukaryotic cells. SCARNA14 belongs to the H/ACA box class of guide RNAs, characterized by a hairpin-hinge-hairpin-tail structure and conserved sequence motifs. Its primary function is to guide the pseudouridylation of specific nucleotides within U2 spliceosomal snRNA, particularly residue U7, thereby modulating the maturation and function of spliceosomal RNAs essential for pre-mRNA splicing[1]. SCARNA14 is a non-coding RNA molecule and does not encode a protein[1].
- Other names
- SCARNA14U100Small Cajal body specific RNA 14scaRNA14
02
Biological functions
Guides post-transcriptional modification, specifically pseudouridylation of U2 spliceosomal small nuclear RNA (snRNA) at uridine 7Involved in the modification of spliceosomal RNAs transcribed by RNA polymerase II, including U1, U2, U4, U5, and U12Regulates snRNA function in pre-mRNA splicing (as inferred from the class of molecules)
03
Disease associations
No direct disease associations or roles are documented for SCARNA14 in the supplied sources. The broader class of scaRNAs/snoRNAs may be perturbed in disease (notably cancer), but no evidence is present specifically for SCARNA14
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