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Target intelligence / Profile preview
Small Cajal body-specific RNA 18B (SCARNA18B)
- Target
- SCARNA18B
- Molecular classification
- Other (classified as a non-coding small nuclear RNA, specifically a small Cajal body-specific RNA, or scaRNA)
01
Overview
Small Cajal body-specific RNA 18B (SCARNA18B) is a member of the scaRNA family, which are small non-coding RNAs that accumulate in Cajal bodies—nuclear sub-organelles implicated in the post-transcriptional modification of spliceosomal RNAs. scaRNAs serve as guide RNAs for the site-specific 2′-O-methylation and pseudouridylation of small nuclear RNAs (snRNAs) involved in pre-mRNA splicing[1][3][5][4]. This molecule is not a receptor, enzyme, transporter, or conventional drug target, and currently has no direct implication in drug interactions, disease mechanisms, or biomarker roles. Its primary function relates to the maturation of snRNAs within the Cajal body.
- Other names
- SCARNA18Bsmall Cajal body-specific RNA 18B
02
Biological functions
Guide for site-specific modification (2′-O-methylation and pseudouridylation) of spliceosomal small nuclear RNAs (snRNAs)
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