Small Cajal body-specific RNA 5 (SCARNA5)

Small Cajal body-specific RNA 5 (SCARNA5), also known as U87, is a small nucleolar RNA of the scaRNA class that specifically localizes to the Cajal body, a nuclear organelle implicated in the biogenesis and modification of spliceosomal snRNPs[1][3][4]. SCARNA5 and other scaRNAs guide site-specific 2′-O-methylation and pseudouridylation of spliceosomal snRNAs (including U1, U2, U4, U5), which are essential for accurate RNA splicing[1][3]. SCARNA5 itself is not a receptor, enzyme, or conventional therapeutic target but instead acts as a non-coding guide RNA involved in RNA modification within the nucleus[1][4]. There is no direct evidence linking SCARNA5 to specific disease mechanisms, nor are there drugs that specifically target or interact with SCARNA5. Notes: - SCARNA5 belongs to a family of small non-coding RNAs involved in post-transcriptional modifications of snRNAs in the Cajal body[1][3][4]. - The best functional characterization relates to its role in guiding modifications on snRNAs, not to being a therapeutic target or drug interaction partner[1][4]. - Some scaRNAs as a broader class may be altered in disease contexts (for example, SCARNA15 in cancer), but there are no specific data associating SCARNA5 with a direct disease role[2][4]. - The entry is correctly specified and is not misspelled, though it is not a typical molecular target as per pharmacological definitions.

Other names

U87scaRNA5small Cajal body-specific RNA U87