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Small Cajal body-specific RNA 7 (SCARNA7)
- Target
- SCARNA7
- Molecular classification
- Small Cajal body-specific RNA, small nucleolar RNA (snoRNA), non-coding RNA, H/ACA box scaRNA
01
Overview
Small Cajal body-specific RNA 7 (SCARNA7) is a member of the small Cajal body-specific RNAs, a subclass of small nucleolar RNAs (snoRNAs) found predominantly in the Cajal bodies within the nucleus[2][3][4][5]. SCARNA7 functions primarily as a guide RNA for the site-specific 2’-O-methylation of U1 snRNA, an essential modification required for proper spliceosome assembly and function[3]. It is classified as an H/ACA scaRNA and is intron-encoded. Recent studies have identified SCARNA7 as a potential biomarker for determining EGFR mutation status in patients with non-small cell lung cancer, indicating a possible diagnostic role but not a direct therapeutic target[1]. No known drugs interact directly with SCARNA7, nor does it serve as a therapeutic target for drug development.
- Other names
- SCARNA7U90small Cajal body-specific RNA 7U90 scaRNA
02
Biological functions
Guide for 2’-O-methylation of snRNA (specifically U1 snRNA)post-transcriptional modification of spliceosomal snRNAsRNA processingregulation of RNA stability and splicing
03
Disease associations
Potential biomarker in non-small cell lung cancer (NSCLC), specifically in association with EGFR mutation status[1]
04
Biomarkers
Marker for EGFR mutation status in NSCLC[1]
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