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Target intelligence / Profile preview
Small-Conductance Calcium-Activated Potassium Channel (SK channel)
- Target
- SK channel
- Molecular classification
- Ion channel, Potassium channel, Calcium-activated potassium channel
01
Overview
Small-conductance calcium-activated potassium (SK) channels are a subtype of potassium channels that are activated by increases in intracellular calcium concentration. They play a crucial role in regulating the excitability of various cell types, including neurons and cardiomyocytes, by mediating membrane hyperpolarization following action potentials. SK channels are encoded by the KCNN1, KCNN2, and KCNN3 genes, forming homo- or heterotetrameric channel complexes. Activation depends on intracellular Ca²⁺ levels and constitutively bound calmodulin, leading to K⁺ efflux and membrane hyperpolarization. Dysfunctions are implicated in cardiac arrhythmias and neurological disorders.
- Other names
- KCa2 channelSK1SK2SK3KCNN1KCNN2KCNN3KCa2.1KCa2.2KCa2.3
02
Mechanism of action
Potassium efflux leading to membrane hyperpolarization
03
Biological functions
Regulation of neuronal excitabilityCardiac repolarizationSpike-frequency adaptationAfterhyperpolarization
04
Disease associations
Cardiac arrhythmiasEpilepsyNeurological disordersExcitability-related diseases
05
Interacting drugs
Apamin
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