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Target intelligence / Profile preview
Small Conductance Calcium-Activated Potassium Channel 1 (SK1)
- Target
- SK1
- Molecular classification
- Ion channel, Potassium channel, Calcium-activated potassium channel
01
Overview
Small conductance calcium-activated potassium channel 1 (SK1) is a calcium-activated potassium channel encoded by the KCNN1 gene. SK channels are tetrameric complexes, each formed from four alpha subunits and activated by intracellular calcium binding to calmodulin. Activation leads to membrane hyperpolarization, inhibiting further cell firing and regulating neuronal excitability and synaptic plasticity. They are expressed throughout the central nervous system, cardiac tissue, and other excitable cells. Altered expression or function has been implicated in several conditions, including chronic atrial fibrillation and neurodevelopmental/psychiatric disorders.
02
Mechanism of action
Modulation of potassium ion flow through calcium-activated channels, leading to membrane hyperpolarization and altered cellular excitability.
03
Biological functions
Regulation of neuronal excitabilityAfterhyperpolarizationSynaptic plasticityRegulation of cardiac excitabilityMembrane hyperpolarization
04
Disease associations
Chronic atrial fibrillationNeurodevelopmental disordersPsychiatric diseases
05
Interacting drugs
Apamin
3 more in the full profile.
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