Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Small conductance calcium-activated potassium channel 3 (SK3)
- Target
- SK3
- Molecular classification
- Potassium channel, Ion channel, Calcium-activated potassium channel
01
Overview
Small conductance calcium-activated potassium channel 3 (SK3) is a member of the SK family of potassium channels, which are activated by increases in intracellular calcium concentration. These channels play a crucial role in regulating neuronal excitability, firing patterns, and synaptic integration across various cell types. Dysregulation of these channels has been implicated in neurological disorders involving abnormal neuronal excitability as well as cardiac arrhythmias due to their role in shaping action potentials.
- Other names
- SK3hSK3SKCA3KCa2.3hSKCNAO41POTASSIUM CHANNEL SUBFAMILY N MEMBER 31
02
Mechanism of action
Blockage of the channel, modulation of calcium sensitivity
03
Biological functions
Regulation of neuronal excitabilityRegulation of firing patternsSynaptic integrationAfterhyperpolarization current (I_AHP) regulationCardiac action potential modulation
04
Disease associations
Neurological disorders (abnormal neuronal excitability)Cardiac arrhythmias
05
Safety considerations
Potential for neurological and cardiac side effects due to widespread distribution and role in excitability
06
Interacting drugs
Tricyclic antidepressants
3 more in the full profile.
Beyond the preview
Go deeper on Small conductance calcium-activated potassium channel 3 (SK3).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Small conductance calcium-activated potassium channel 3 (SK3).