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Target intelligence / Profile preview
Small conductance calcium-activated potassium channel protein 1 (KCNN1)
- Target
- KCNN1
- Molecular classification
- Ion channel, Potassium channel, Calcium-activated potassium channel
01
Overview
Small conductance calcium-activated potassium channel protein 1 (KCNN1), also known as KCa2.1 or SK1, is a voltage-independent, calcium-activated potassium channel. It is expressed in neurons and cardiac tissue, regulating neuronal excitability and potentially influencing atrial electrophysiology. KCNN1 mediates potassium ion transfer in response to intracellular calcium increases, contributing to the afterhyperpolarization (AHP) that regulates neuronal firing. Alterations have been implicated in pain modulation, cancer, and arrhythmogenesis. Apamin blocks KCNN1 activity.
- Other names
- KCa2.1SK1SKCA1hSK1
02
Mechanism of action
Channel blocker (Apamin)
03
Biological functions
Potassium ion transportRegulation of neuronal excitabilityRegulation of chemical synaptic transmissionRegulation of afterhyperpolarization (AHP)
04
Disease associations
Pain modulationCancerArrhythmogenesis
05
Safety considerations
Potential for neurological side effects (though less than current inhibitors under investigation)Effects on atrial electrophysiology and arrhythmogenesis
06
Interacting drugs
Apamin
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