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Target intelligence / Profile preview
Small Conductance Calcium-Activated Potassium Channel Protein 3 (KCNN3)
- Target
- KCNN3
- Molecular classification
- Ion channel, Potassium channel, Calcium-activated potassium channel
01
Overview
KCNN3, also known as SK3 or KCa2.3, is a voltage-independent potassium channel activated by intracellular calcium. It mediates potassium ion transport across cell membranes, contributing to membrane hyperpolarization and regulating neuronal excitability. The channel is regulated by calmodulin and is specifically blocked by apamin. KCNN3 is widely expressed, especially in the brain and smooth muscle, and is associated with diseases like Zimmermann-Laband Syndrome.
- Other names
- SK3KCa2.3
02
Mechanism of action
Channel blocker
03
Biological functions
Potassium ion transmembrane transportRegulation of neuronal excitabilitySynaptic transmissionCalmodulin binding
04
Disease associations
Zimmermann-Laband SyndromeSleep apneaSudden infant death syndrome (SIDS)Age-dependent decline in learning/memory/synaptic plasticityVascular disorders
05
Interacting drugs
Apamin
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