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Target intelligence / Profile preview
Small Conductance Calcium-Activated Potassium Channel Subfamily N Member 2 (KCNN2)
- Target
- KCNN2
- Molecular classification
- Ion channel, Potassium channel, Calcium-activated potassium channel
01
Overview
KCNN2, also known as KCa2.2 or SK2, is a member of the small conductance calcium-activated potassium channel family. It encodes an integral membrane protein that forms a voltage-independent, calcium-activated potassium channel. This channel plays a crucial role in regulating neuronal excitability by mediating the transmembrane transfer of potassium ions in response to increases in intracellular calcium concentration, leading to membrane hyperpolarization following action potentials and contributing to the slow component of synaptic afterhyperpolarization (AHP) in neurons. Dysregulation has been linked to anxiety and Angelman syndrome.
- Other names
- KCa2.2SK2
02
Mechanism of action
Channel blocker
03
Biological functions
Regulation of neuronal excitabilitySynaptic afterhyperpolarization (AHP)Transmembrane transfer of potassium ionsModulation of synaptic activityModulation of synaptic plasticity
04
Disease associations
Anxiety/stress modulationAngelman syndrome-related synaptic dysfunction
05
Interacting drugs
Apamin
1 more in the full profile.
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