Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Small Conductance Calcium-Activated Potassium Channel Subfamily N Member 3 (KCNN3)
- Target
- KCNN3
- Molecular classification
- Ion channel, Potassium channel, Calcium-activated potassium channel
01
Overview
KCNN3 encodes a small conductance calcium-activated potassium channel protein (SK3) that regulates neuronal excitability by contributing to the afterhyperpolarization (AHP) following action potentials. It also plays a role in vascular tone regulation and is hormonally regulated in reproductive tissues. Dysregulation of KCNN3 is associated with Zimmermann-Laband Syndrome 3 and has potential links to sleep apnea, SIDS and hypertension.
- Other names
- SK3KCa2.3
02
Mechanism of action
Channel blocker; Binds calmodulin to regulate calcium binding.
03
Biological functions
Regulation of neuronal excitabilityAfterhyperpolarization (AHP)Vascular tone regulationTransmembrane transport of potassium ions
04
Disease associations
Zimmermann-Laband Syndrome 3Sleep apnea (potential)Sudden infant death syndrome (SIDS) (potential)Hypertension (potential)
05
Safety considerations
Altered neuronal excitabilityCardiovascular effects
06
Interacting drugs
Apamin
1 more in the full profile.
Beyond the preview
Go deeper on Small Conductance Calcium-Activated Potassium Channel Subfamily N Member 3 (KCNN3).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Small Conductance Calcium-Activated Potassium Channel Subfamily N Member 3 (KCNN3).