Small Conductance Chloride Channel Protein (SCCC)

Small conductance chloride channel proteins are integral membrane proteins that facilitate the selective passage of chloride ions (Cl⁻) across cellular membranes. These channels play a crucial role in maintaining cellular ion homeostasis, regulating cell volume, and contributing to the electrical excitability of various cell types. Most small conductance chloride channels belong to the CLC family (Chloride Channel family). Each CLC channel is typically a homodimer, with each subunit forming its own pore for independent ion conduction. Chloride flows down its electrochemical gradient when these channels open. Dysfunction or mutations in small conductance chloride channel proteins can lead to various diseases like myotonia congenita, caused by mutations in ClC‐1. These channels can be modulated pharmacologically using drugs acting as inhibitors or activators.

Other names

CLC family chloride channelsChloride channelCl⁻ channel

Modulation of chloride ion flux across cell membranes.