Small cysteine and glycine repeat containing protein 10 (SCYGR10)

Small cysteine and glycine repeat containing protein 10 (SCYGR10) is a member of the keratin-associated protein (KRTAP) family, specifically within the subfamily of small cysteine and glycine repeat-containing proteins[1][2][4][6]. These proteins are synthesized during hair matrix cell differentiation and are involved in the formation, structure, and rigidity of hair fibers through extensive disulfide bond cross-linking with hair keratins, contributing to the mechanical strength of the hair shaft[1][4][6]. SCYGR10 and related SCYGR genes are clustered on human chromosome 2q36.3; due to allelic polymorphisms, some gene variants are non-coding, and the primary human reference genome version is non-coding for this gene[1][2]. While important for hair biology, SCYGR10 is not a recognized therapeutic target, drug receptor, enzyme, or transporter and there are no known drugs, biomarker applications, or safety profiles associated with this molecule[1][2][4][6]. In several genomic resources, the gene may be annotated as a pseudogene, indicating a lack of known functional protein expression in some alleles[1][2][4]. Key points: - **SCYGR10 is not a therapeutic target**; it is a structural keratin-associated protein involved in hair formation[1][2][4][6]. - There is **no evidence of drug interactions, biomarker use, or direct disease involvement**. - Several aliases point to its inclusion in the KRTAP family; some designations emphasize its pseudogene status[1][2][4]. - Entries using "pseudogene" or indicating the gene is non-coding for most reference alleles mean it is **not a typical protein-coding therapeutic or diagnostic target**, and its potential for drug targeting is null[1][2].

Other names

Small cysteine and glycine repeat-containing protein 10SCYGR10KRTAP28p2KRTAP28-10Keratin-associated protein 28 family pseudogene 2keratin associated protein 28-910