Small cysteine and glycine repeat-containing protein 5 (SCYGR5)

Small cysteine and glycine repeat-containing protein 5 (SCYGR5), also known as keratin-associated protein 28-5 (KRTAP28-5), is a cysteine-rich protein highly expressed in the hair cortex, where it forms part of the interfilamentous matrix embedding hair keratin intermediate filaments. These keratin-associated proteins are essential for generating a rigid and resilient hair shaft, primarily by cross-linking with hair keratins via disulfide bonds due to their cysteine content. SCYGR5 belongs to the larger family of keratin-associated proteins (KRTAPs), which are not receptors, enzymes, or therapeutic targets in current medical research. SCYGR5 does not have known roles in disease or as a drug target, and its primary biological function is structural in the differentiation of hair fibers. SCYGR5 is an 85-amino-acid protein, molecular weight ~8.2 kDa. It is located predominantly within the intermediate filament of hair cortex cells. No literature supports a direct role in disease, therapy, or biomarker applications. There is no evidence that SCYGR5 is a therapeutic target, receptor, enzyme, transporter, or member of any major signal transduction pathway. Its function is tightly restricted to hair fiber structure.

Other names

Small cysteine and glycine repeat containing 5SCYGR5KRTAP28-5Keratin-associated protein 28-5keratin associated protein 28-5SCGR5