Small cysteine and glycine repeat-containing protein 8 (SCYGR8)

Small cysteine and glycine repeat-containing protein 8 is part of the keratin-associated protein family (specifically KRTAP28-8), characterized by a high cysteine and glycine content, which enables extensive disulfide bonding and structural association with keratin intermediate filaments in the hair shaft. This protein contributes to the physical properties of hair, such as strength, rigidity, and flexibility, but has no known enzymatic, receptor, or transporter functions. It is not associated with disease nor targeted by therapeutic drugs in current biomedical literature. Key molecular traits: Protein length: 108 amino acids; molecular mass ≈ 10 kDa. Family: Ultrahigh sulfur keratin-associated proteins (high cysteine content, subfamily 28). Localization: Predicted to be in intermediate filament structures, mostly in hair/wool. Clinical relevance: No known disease association or use in diagnostics, patient selection, or drug interaction.

Other names

Keratin-associated protein 28-8KRTAP28-8SCYGR8small cysteine and glycine repeat containing 8