Small heterodimer partner (SHP (also known as NR0B2))

Small heterodimer partner (SHP; NR0B2) is an atypical orphan nuclear receptor primarily acting as a transcriptional corepressor via protein-protein interactions, repressing the activity of multiple nuclear receptors and transcription factors involved in lipid, glucose, and bile acid metabolism, as well as innate immunity and inflammation. Unlike conventional nuclear receptors, SHP lacks a DNA-binding domain but retains a ligand-binding domain, allowing it to regulate gene expression by interacting with other nuclear and cytoplasmic proteins. SHP plays crucial roles in maintaining metabolic homeostasis and immune responses, and dysregulation of SHP function is implicated in many metabolic and inflammatory diseases. Although currently lacking direct therapeutic ligands, SHP is considered a promising target for metabolic and immune diseases, with ongoing research into its regulatory networks and small-molecule modulators.

Other names

NR0B2Nuclear receptor subfamily 0 group B member 2SHP

Drugs or modulators act by promoting SHP induction or corepressor recruitment, leading to transcriptional repression of metabolic and inflammatory target genes