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Target intelligence / Profile preview
Small Hydrophobic Protein of Respiratory Syncytial Virus A (SH)
- Target
- SH
- Molecular classification
- Viroporin, Type II transmembrane protein
01
Overview
The small hydrophobic (SH) protein is a viral protein encoded by the human respiratory syncytial virus (RSV), specifically in subgroup A strains. It consists of 64 amino acids and functions as a pH-dependent ion channel (viroporin). The SH protein inhibits apoptosis, modulates host cell secretory pathways, and can inhibit tumor necrosis factor alpha (TNF‐α) signaling. It is not essential for viral entry or syncytium formation but contributes to full virulence. Inhibitors like pyronin B block channel activity, suggesting a potential antiviral drug target.
- Other names
- RSV-A SH proteinSH protein
02
Mechanism of action
Inhibition of ion channel activity
03
Biological functions
Ion channel activityInhibition of apoptosisModulation of TNF-α signalingModification of host cell secretory pathways
04
Disease associations
InfectionRespiratory Syncytial Virus infection
05
Safety considerations
Targeting viral proteins can lead to resistance mutations.
06
Interacting drugs
Pyronin B
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